Transgene-Induced Chromosomal Rearrangement With Aberrant Human Vascular Endothelial Growth Factor at the Optic Fissure Leads to Uveal Coloboma in Mice.

چکیده

The pathogenesis of uveal coloboma, a potentially blinding congenital ocular malformation, is incompletely understood. We characterize a novel mouse model of coloboma, Retinal and Iris Coloboma (RICO). Transgenic mice were created by insertion of a human vascular endothelial growth factor-165…

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موضوعات مرتبط

• تصویربرداری و تشخیص