Investigative ophthalmology & visual science۲۰۲۴۷ استنادنمایه شده در PubMed
Josephine Q N Nguyen, Wojtek Drabarek, Aïsha M C H J Leeflang, Tom Brands, Thierry P P van den Bosch, Robert M Verdijk, Harmen J G van de Werken, Job van Riet, Dion Paridaens, Annelies de Klein, Erwin Brosens, Emine Kiliç, Rotterdam Ocular Melanoma Study Group
چکیده
Unfortunately, treatment of patients with uveal melanoma (UM) with metastatic disease is limited. Twenty percent of patients with UM harbor a mutation in the splicing factor gene SF3B1, suggesting that aberrant spliceosome function plays a vital role in tumorigenesis. Splicing inhibitors exploit…
متن کامل چکیده در سایت ناشر در دسترس است.
DOI: 10.1167/iovs.65.12.11