Nobiletin restores corneal circadian transcriptome organization and mitigates ocular surface pathology in high-fructose-induced metabolic dysfunction.

چکیده

Excess fructose intake promotes metabolic syndrome and disrupts peripheral circadian programs, but its effects on the ocular surface are unclear. This study tested whether a high-fructose diet reprograms the corneal circadian transcriptome and whether the clock-modulating flavonoid nobiletin…

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